Complex Sciences. First International Conference, Complex 2009, Shanghai, China, February 23-25, 2009. Revised Papers, Part 1

Research Article

Time Dependent Virus Replication in Cell Cultures

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  • @INPROCEEDINGS{10.1007/978-3-642-02466-5_63,
        author={Juan Ochoa and Andreas Voigt and Heiko Briesen and Kai Sundmacher},
        title={Time Dependent Virus Replication in Cell Cultures},
        proceedings={Complex Sciences. First International Conference, Complex 2009, Shanghai, China, February 23-25, 2009. Revised Papers, Part 1},
        proceedings_a={COMPLEX PART 1},
        year={2012},
        month={5},
        keywords={Virus Replication Influenza A Cellular viral Resistance},
        doi={10.1007/978-3-642-02466-5_63}
    }
    
  • Juan Ochoa
    Andreas Voigt
    Heiko Briesen
    Kai Sundmacher
    Year: 2012
    Time Dependent Virus Replication in Cell Cultures
    COMPLEX PART 1
    Springer
    DOI: 10.1007/978-3-642-02466-5_63
Juan Ochoa,*, Andreas Voigt, Heiko Briesen1, Kai Sundmacher
  • 1: Max Planck Institute for Complex Technical Systems
*Contact email: diaz@mpi-magdeburg.mpg.de

Abstract

We present in this report a stochastic model for the virus replication of influenza A in a cell culture. We consider not only the infection process of individual cells but also the number of intracellular components expressed in virus equivalent. Given that this expression is non constant in time we suggest a variable threshold, related to a viral resistance in the cell population, that could explain the time variation in the viral expression in the cell seen in experiments.