8th International Conference on Body Area Networks

Research Article

Semi-artificial living neuronal network consists of neuronal units derived from different species

  • @INPROCEEDINGS{10.4108/icst.bodynets.2013.253917,
        author={Alice Shuta and Suguru Kudoh},
        title={Semi-artificial living neuronal network consists of neuronal units derived from different species},
        proceedings={8th International Conference on Body Area Networks},
        publisher={ICST},
        proceedings_a={BODYNETS},
        year={2013},
        month={10},
        keywords={mixed dissociated culture ca2+ imaging synaptic connection},
        doi={10.4108/icst.bodynets.2013.253917}
    }
    
  • Alice Shuta
    Suguru Kudoh
    Year: 2013
    Semi-artificial living neuronal network consists of neuronal units derived from different species
    BODYNETS
    ACM
    DOI: 10.4108/icst.bodynets.2013.253917
Alice Shuta,*, Suguru Kudoh1
  • 1: Kwansei Gakuin University
*Contact email: alice.shuta@gmail.com

Abstract

The re-connection technology for neuronal circuit complements the signal from a brain and transmits it to a peripheral system (body). As a second best plan to reconstruct the neuronal connection, the transplantation of a prosthetic circuit consisting of electrical circuit and / or living neuronal circuit into the patient has been proposed. The semi-artificial living neuronal circuit is useful as a buffer circuit of the brain-device interface. To elucidate characters of the living components of the brain is critical for constructing a functional semi-artificial neuronal circuit. This study confirmed by Ca2+ imaging that functional connections could be formed between neurons derived from different distant species. In addition, the degree and spatiotemporal pattern of the activity in the mixed neuronal circuit was changed by manipulations of the synaptic strength. Especially, neuronal electrical events were strongly activated by the abolishment of inhibitory synaptic inputs. Not only activity pattern but also connectivity between rat and chick neuron was changed by the modification of synaptic efficacy. These results suggested that the mixed circuit of neurons derived from chick and rat is critical model case of an artificial living neuronal circuit.