Intelligence of reconstructed biomolecular motor system

Collective motion is a fascinating example of coordinated behavior of self-propelled objects, which is often associated with the formation of large scale patterns. Nowadays, in vitro gliding assay is being considered a model system to experimentally investigate various aspects of group behavior and pattern formation by self-propelled objects. In this work, we have demonstrated the collective motion of kinesin driven microtubules by regulating mutual interaction among the gliding microtubules, by employing depletion force among them. Proper regulation of the mutual interaction among the gliding microtubules through employment of the depletion force was found to allow the exhibition of collective motion and stream pattern formation by microtubules. We also discuss how collectively moving microtubule on kinesin coated elastomer substrate response to external stimuli such as mechanical stresses.